BioWorld

RNA-targeting CRISPR-Cas13 and engineered U1 correct variants in Stargardt disease

Disruption of alternative splicing can generate abnormal mRNA variants, producing nonfunctional proteins or triggering ...
JSTOR Daily

Genome-wide discovery of natural variation in pre-mRNA splicing and prioritising causal alternative splicing to salt stress response in rice

• Pre-mRNA splicing is an essential step for the regulation of gene expression. In order to specifically capture splicing variants in plants for genome-wide association studies (GWAS), we developed a ...
EurekAlert!

NUS and A*STAR researchers discover cell-type-specific link between alternative splicing and autoimmune disease inheritance

Computational biologists from the National University of Singapore (NUS) have uncovered how RNA splicing – a crucial process for isoform expression and protein diversity - is regulated across ...
Health And Pharma

Rewiring RNA: Antisense RNA Therapy Exposes a New Weakness in Pancreatic Cancer

Researchers at CSH Laboratory identified an oncogenic SRSF1–AURKA–MYC circuit driving pancreatic ductal adenocarcinoma.

Short-circuiting pancreatic cancer: A potential RNA therapy

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreas cancer. It's also the most common form of the ...
BioWorld

Vigeneron’s mRNA trans-splicing gene therapy for Stargardt disease receives IND clearance

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...