The Indianapolis Colts lost veteran defensive end Tyquan Lewis for the remainder of their tilt with the Los Angeles Chargers. Lewis went down with a groin injury and was ruled out for the rest of the game. Shortly after, fellow defensive end Samson Ebukam was also ruled out with a knee injury.

INGLEWOOD, Calif. — The Colts have lost two defensive ends in Sunday’s game against the Chargers. Veteran defensive end Tyquan Lewis left the game in the first half with a groin injury, and he was ruled out shortly after the trainers examined Lewis in the locker room.

The Indianapolis Colts have a couple of weeks to mull roster moves as they try to maintain the AFC's best record. Should they trade for a pass rusher?

Through six weeks, he finds himself squarely in the MVP conversation, and The Ringer's Diante Lee laid out his candidates, placing Jones at seventh overall out of eight possible entries. However, Lee pumps the brakes on Jones' MVP argument.

The Colts have shocked the NFL world by being one of the best teams in the league. Backup quarterback Anthony Richardson suffered a bizarre injury last week in pregame warmups. Indianapolis added veteran Brett Rypien to provide relief after Richardson was placed on injured reserve.

Edgerrin James joined the FOX NFL crew to break down whether the Indianapolis Colts can sustain their early success. He also discussed with Rob Gronkowski and Julian Edelman whether the New England Patriots are legitimate contenders to challenge the Buffalo Bills in the AFC East.

The Indianapolis Colts are heading into a high-stakes clash with the Los Angeles Chargers for positioning in the AFC.