This study addresses the structural basis of voltage-activation of BK channels using atomistic simulations of several microseconds, to assess conformational changes that underlie both voltage-sensing ...

Opening and closing ion channels changes the membrane potential. When the neuron is triggered, it activates voltage-gated sodium channels at the beginning of the axon. This causes an influx of ...

you have to have the right combination of ion channels and transporters." More information: Shridhar Sanghvi et al, Functional large-conductance calcium and voltage-gated potassium channels in ...

Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

They calculated the expected electrical current measurements until finally, they generated recordings that appeared to be ion channels, which convinced them that they were on the right track. Their ...

(You may know that dihydropyridines are widely used antihypertensive drugs that reduce blood pressure by inhibiting the calcium channels that provide the calcium influx that supports contraction - ...

This important computational study investigates homeostatic plasticity mechanisms that neurons may employ to achieve and maintain stable target activity patterns. The work extends previous analyses of ...

In a new study, a team led by medical researchers at The Ohio State University determined that these vesicles contain an ion channel – a protein that opens a corridor allowing electrical charges ...