My research focuses on assessing how the highly conserved DREAM transcriptional repressor complex maintains the germ vs. soma cell fate decision during embryogenesis. After a flurry of cell divisions ...
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Understanding the role of LSD1 in cellular processes and diseaseA new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...
It was subsequently found to drive degradation of subunits in a transcriptional repressor complex ‘LHC’, comprised of the histone demethylase LSD1, the histone deacetylase HDAC1 (or HDAC2 ...
EZH2 is a well-known oncogene found in solid tumors and has also been identified as a transcription repressor ... mediated methylation regulates PARP1 transcriptional and oncogenic activity ...
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