Most adults with glioblastoma die within 1-2 years of diagnosis. Standard care is currently surgical resection, when possible, with subsequent radiotherapy. Addition of chemotherapy could provide ...

Glioblastoma multiforme (GBM) is a very aggressive and hard-to-treat brain cancer. Even with improvements in surgery, ...

Temozolomide is an orally available, small-molecule alkylating agent used as the standard-of-care chemotherapy for glioblastoma multiforme and other high-grade brain tumors. As a DNA-methylating ...

The current standard of care for patients with newly diagnosed GBM consists of maximal surgical resection, fractionated radiotherapy with concurrent temozolomide, an oral alkylating ...

Glioblastoma is the most aggressive and most ... combining navtemadlin with other DNA-damaging chemotherapy, such as temozolomide, could increase the rates at which cancer cells die.

In 2021, he was diagnosed with a stage four glioblastoma, external and told he had 12 to 18 months to live. He approached the BBC after reading about the temozolomide patient who had received ...

These efforts culminated recently in the release of long-term survival data from a 695-patient, phase 3 pivotal trial of Optune in combination with TMZ for the treatment of newly diagnosed GBM ...

Reirradiation with concurrent Temodar is a safe salvage option ... whereas the median OS for patients with IDH wildtype glioblastoma was 8.7 months. Gy fractions: the division of a total radiation ...