Dissection of the signalling pathways mediating apoptosis — controlled cell death ... and extrinsic apoptotic cascades, such as BCL-2, TNF, NF-κB and p53. This interest in part stems ...

“I anticipated that our knowledge of this pathway and my clinical training ... a receptor for TNF-related apoptosis-inducing ligand (TRAIL). “We succeeded in obtaining an anti-DR5 antibody ...

The cytokines considered most relevant to the pathogenesis of HF are tumor necrosis factor-a (TNF) and interleukin(IL)-6, and they have been the most extensively studied in this disorder.

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...

However, since TNF is a cytokine with pleiotropic effects, interfering with many immunological functions and pathways ... thus reducing cell recruitment; apoptosis of monocytes and T cells ...

The role of TNF-α, a key cytokine secreted by Ly6C^high macrophages, which can either promote FAP apoptosis and reduce ... FAPs secrete IL-6 through STAT3 pathway activation, contributing to ...