This new article publication from Acta Pharmaceutica Sinica B, discusses the structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Receptor-interacting ...
A recent study posted to the bioRxiv* preprint server illustrated the optimization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 3 (NSP3) macrodomain (Mac) ...
Receptor tyrosine kinase-like orphan receptor 1 (ROR1), a receptor tyrosine kinase activated by Wnt5, is mainly expressed during fetal development and plays a crucial role in processes such as ...
In a recent study posted to the bioRxiv* preprint server, researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' main protease (Mpro), ...
Genentech Inc. presented data on structure-based lead optimization of orally bioavailable hematopoietic progenitor kinase 1 (HPK1) inhibitors. HPK1 is a negative regulator of T-cell receptor signaling ...
Based on the novel scaffold generated by Chemistry42, ISM6331 is a highly novel molecule with best-in-class potential. Being a pan-TEAD inhibitor, ISM6331 has shown potent efficacy at a low dose, as ...
VANCOUVER, BC / ACCESS Newswire / November 20, 2025 / Onco-Innovations Limited (ONCO:CA)(OTCQB:ONNVF)(Frankfurt:W1H, WKN:A3EKSZ) ("Onco" or the "Company") is pleased ...
Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...
Results that may be inaccessible to you are currently showing.
Hide inaccessible results