Vividion Publishes Discovery of WRN Inhibitor VVD-214 in Journal of Medicinal Chemistry

Vividion publishes manuscript detailing the discovery and optimization of VVD-214, the company’s covalent inhibitor of WRN.
sciencex

Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

A publication from Acta Pharmaceutica Sinica B discusses the structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Receptor-interacting serine/threonine-protein ...
BioWorld

Preclinical characterization of the dual DGK-α/ζ inhibitor BMS-986408

Researchers from Bristol Myers Squibb Co. disclosed the structure and presented preclinical data for the dual inhibitor of diacylglycerol kinases (DGK) α and ζ, BMS-986408. Optimization of a ...
EurekAlert!

Insilico Medicine announces potential best-in-class pan-TEAD inhibitor candidate ISM6331 targeting advanced solid tumors

Based on the novel scaffold generated by Chemistry42, ISM6331 is a highly novel molecule with best-in-class potential. Being a pan-TEAD inhibitor, ISM6331 has shown potent efficacy at a low dose, as ...