New scientific methods could one day render animal studies—the standard in research laboratories for more than 100 ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

A research conducted by Juan Méndez, Head of the DNA Replication Group of the Spanish National Cancer Research Centre (CNIO), sheds light on the molecular mechanisms of ageing of the stem cells ...

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This ...

The technology, called the Viral-Engineered RNA-based Activation System (VERAS), hijacks the virus's own replication ...

Mouse ES cells present active origin firing and replication forks that progress slowly throughout S phase. These features are integral aspects of genome replication ensuring genome integrity in ES ...

ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.

In cell division, nothing is as important as the precise replication of billions of genetic letters that make up DNA. Since this genomic integrity is so fundamental to survival, scientists had assumed ...

The technology, called the Viral-Engineered RNA-based Activation System (VERAS), hijacks the virus's own replication ...