Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

In a multicenter, 8-week trial in 417 essential hypertensive patients eplerenone 50, 100, or 400 mg o.d. or 25, 50 or 200 mg b.i.d. was compared with spironolactone 50 mg b.i.d. or placebo.

In a new study, de Souza and colleagues demonstrate the potent blood pressure lowering effect of low-dose spironolactone ... such as eplerenone, and studies on these selective agents should ...