Sure enough, SGLT2 inhibition with canagliflozin significantly reduced the previously elevated number of PD-L1-positive senescent cells in HFD-fed mice. Conversely, suppression of immune cells ...

The discovery offers insight into why shift workers experience metabolic disruption, which could lead to new therapies for ...

Researchers have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer ...

Transplanting microglia derived from human stem cells into mice reveals new possibilities for treating neurodegenerative eye diseases.

Renal glucose reabsorption involves two transporter families: the SGLTs secondary active Na + /D-glucose co-transporters located at the brush border of tubular cells (SGLT2 and SGLT1) and the ...

Researchers at the University of Alberta have pinpointed two proteins that could serve as markers for identifying patients ...

The new technique could kill a wide range of cancer cells, including breast and prostate A newly-discovered part of our immune system could be harnessed to treat all cancers, say scientists.

Prof. Fabry emphasizes, "Our discovery that immune cells can create high contraction forces for a brief period of time is only one example of how this new method will lead to fundamental discoveries.

A recent analysis of clinical trial data reveals that the SGLT2 inhibitor canagliflozin benefited patients across all age categories. The findings were presented at ASN Kidney Week 2024 October 23 ...

Of note, a similar proportion of patients in the empagliflozin and placebo groups (43% and 40%, respectively) were using an SGLT2 inhibitor during the post-trial period, they wrote in the New ...

Nov. 6, 2024 — Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis. Researchers have ...

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system. Microglia, the primary immune cells of the central ...