When that O sequence is mutated, the repressor can no longer bind, leaving the entire operon induced or "unrepressed." O c mutants are therefore constitutively able to metabolize lactose ...

Silencer sequences that reduce transcription may also be present. These sequences bind to repressor proteins and turn transcription off by interfering with RNA polymerase binding. Sometimes ...

compact repressor domains were identified through high-throughput screening of over 30,000 diverse domains across the tree of life Structural, functional, and sequence analyses provided novel ...