Alternative RNA splicing tied to schizophrenia-like behaviors in animal models

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A ...
News Medical

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

Tokyo Medical and Dental University (TMDU) researchers harness long-read RNA sequencing to decode genetic intricacies and disease links. Alternative splicing, a process where a single gene can give ...
Nature

Why rings of RNA could be the next blockbuster drug

RNA-based vaccines were the heroes of the COVID-19 pandemic. They set records for the highest-grossing drug launches in history, and their development was recognized in this year’s Nobel Prize in ...
The Cornell Daily Sun

Weill Cornell Researchers Develop New Technique to Investigate Impact of Abnormal RNA Splicing on Disease

Researchers in the Landau lab, led by Dr. Dan Landau, hematology and medical oncology, recently developed a new technique to investigate how mutations in RNA splicing can lead to clonal hematopoiesis ...
Science Daily

Model demonstrates how RNA splicing defects contribute to Alzheimer's disease

Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled over ...
Labmate Online

Antisense oligonucleotide has disrupted a three-part oncogenic circuit in pancreatic ductal adenocarcinoma

Cold Spring Harbor Laboratory researchers have reported that a bespoke antisense oligonucleotide can disrupt alternative ...
Kaleido Scope

UAB researchers uncover protein SRSF1’s uncommon ability to bind and unfold RNA G-quadruplexes

RNA transcription is the genomic process in which a cell produces a duplicate of a gene’s DNA sequence. Present in both DNA and RNA sequences, a G-quadruplex (GQ) is a structure of four guanine bases ...