Polycomb group (PcG) and trithorax group (TrxG) proteins are evolutionarily conserved regulatory factors that were initially discovered in Drosophila. PcG/TrxG proteins regulate chromatin structure ...

Small proteins called histones are tasked with ... Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression, Genes & Development ...

Example of a tumour obtained by reducing the expression levels of a Polycomb protein. On the left is an example of precursor tissue of the eye during normal development. On the right, a tumour has ...