Polycomb group (PcG) and trithorax group (TrxG) proteins are evolutionarily conserved regulatory factors that were initially discovered in Drosophila. PcG/TrxG proteins regulate chromatin structure ...

Example of a tumour obtained by reducing the expression levels of a Polycomb protein. On the left is an example of precursor tissue of the eye during normal development. On the right, a tumour has ...

They remain functional despite the lack of a well-defined structure, contradicting the notion that structure defines the function of a protein. The structure of chromatin bound by Polycomb ...