9 Central sensitisation can be seen as an umbrella term,9 the main characteristics of which are: Hyperalgesia is an increased pain response to normally painful stimuli and may be as a result of ...

In the periphery, TRPV1 is activated by exposure to noxious heat and protons and is responsible for peripheral heat hyperalgesia. Central sensitization is a major problem in pain conditions across ...

They have long been considered a potential target for non-opioid-based pain treatment; however, previous attempts to target this pathway have been met with two challenges. First, repeated exposure to ...

Systemic inhibition of interleukin (IL)-1 with rilonacept (IL-1 Trap) could be an effective therapy for the pain and inflammation ... ankle joint synovitis and hyperalgesia induced by monosodium ...