InflaRx Reports New Mechanistic Data for Izicopan Supporting its Potential as a Best-in-Class C5aR Inhibitor

InflaRx N.V. (Nasdaq: IFRX), a biopharmaceutical company pioneering anti-inflammatory therapeutics by targeting the ...
Nature

Cytochrome P450 CYP121A1 Inhibitors in Mycobacterium Tuberculosis

Cytochrome P450 CYP121A1 is a pivotal enzyme in Mycobacterium tuberculosis, playing an essential role in the biosynthesis of mycocyclosin via a phenol coupling reaction of the dipeptide ...
EurekAlert!

Mechanisms and related cellular and molecular pathways of liver injury caused by targeted therapy and ICIs, alone or in combination (IMAGE)

Tyrosine kinase inhibitors (TKIs) are metabolized via the cytochrome P450 pathway, which may be associated with the production of toxic intermediates. These drugs can also induce oxidative stress and ...
ascopubs.org

Human cytochrome P450 and UDP-glucuronosyltransferase reaction phenotyping of MPC-3100, an oral HSP90 inhibitor.

Phase II study to evaluate efficacy and safety of irinotecan, capecitabine, and bevacizumab in patients with metastatic colorectal cancer (mCRC). This is an ASCO Meeting Abstract from the 2011 ASCO ...
BioWorld

Guangzhou Vinnocent Pharmaceutical presents new inhibitors of CYP11B1 and CYP11B2

Guangzhou Vinnocent Pharmaceutical Ltd. has divulged cytochrome P450 11B1, mitochondrial (CYP11B1; steroid 11-β-monooxygenase) and cytochrome P450 11B2, mitochondrial (CYP11B2; aldosterone synthase; ...
ascopubs.org

Effects of strong cytochrome P450 (CYP)3A4 inducers/inhibitors on the pharmacokinetic (PK) profile of anamorelin in healthy volunteers.

Gut microbiome alterations in breast cancer survivors with cancer-related fatigue. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This abstract does not include a full text ...
News Medical

New inhibitor shows promise in fighting obesity and preventing heart disease

An interdisciplinary research team at The University of Texas at San Antonio has successfully developed an innovative inhibitor that shows promise in fighting obesity and potentially preventing heart ...