And since Neil Patrick Harris is filling that role in the newly announced Marvel’s Deadpool VR, Reynolds responded exactly how you’d imagine: by taking over as Doogie Howser.

Ryan Reynolds/YouTube; ABC Photo Archives/Disney General Entertainment Content via Getty Ryan Reynolds in 'Doogie Howser M.D.' spoof; Neil Patrick Harris in a 1989 photo from the real thing More ...

Neil Patrick Harris is pictured in a promotional image from the ABC show, "Doogie Howser, M.D.," circa 1990.

Harris credits some of that to “my wonderful parents,” and also admits that part of that came from Bochco, his boss on “Doogie Howser,” and the man he considers one of his early mentors in ...

Neil Patrick Harris took to his Instagram account to share a rare family photo featuring his twins, Harper and Gideon.

Neil Patrick Harris is an American actor born in Albuquerque, N.M. Harris rose to fame at a young age as a genius, teenaged doctor in "Doogie Howser, M.D." He went on to play Max in "Capitol ...

In the video, Reynolds can be seen wearing a lab coat and glasses, in an apparent imitation of Harris in the latter’s star-making role, as a teenage physician in the sitcom Doogie Howser, MD.

Ryan Reynolds spoofs “Doogie Howser M.D.”, calls Neil Patrick Harris a 'butthole' for stealing Deadpool game role Harris is set to voice the merc with a mouth in 'Marvel’s Deadpool VR' for ...