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NFL Week 12 picks and predictions, straight-up and ATS

NFL Week 12 predictions, ESPN matchup predictor's picks, win probabilities for this week

Some of the site's predictions differ from NFL Week 12 odds and other NFL Week 12 picks for NFL Week 12 games. How correct will the analytics be this week? Click on each game for more NFL Week 12 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

· 17h · on MSN

NFL Week 12 odds, predictions, expert picks: Can Cowboys upset Eagles? Will Colts take down Chiefs?

RotoBaller on MSN · 2d

NFL Week 12 Predictions: Picks and Analysis for Every Football Game

National predictions for Detroit Lions vs New York Giants

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· 1h · on MSN

Detroit Lions vs New York Giants picks: A pre-Thanksgiving trap game?

Six Free Press sports writers make score predictions for the Detroit Lions vs New York Giants game Sunday, Nov. 23, 2025 at Ford Field.

· 17h · on MSN

New York Giants vs. Detroit Lions: 6 keys to victory in Week 12

· 20h

Lions News: National predictions for Detroit Lions vs. New York Giants

MLive · 1d

Giants’ starting QB out for Lions matchup, former No. 1 overall pick will start

The Lions’ Week 12 opponents, the New York Giants, will be without dual-threat rookie quarterback Jaxson Dart for the second straight game on Sunday while he remains in the NFL’s concussion protocol.

· 1d

Who Has Edge in Lions' Matchup with Giants?

· 1d

Lions, Giants injury designations: Terrion Arnold, Kerby Joseph OUT

17hon MSN

Week 12 NFL player props, odds, picks: Back Sam Darnold Over 240.5 passing yards in Sunday NFL prop bets

The SportsLine Machine Learning Model AI has locked in its top Week 12 NFL prop picks for players like Sam Darnold, Quinshon Judkins and Amon-Ra St. Brown

6abc Action News

2026 NFL free agency: Early top-25 ranking and predictions

We listed the NFL's top 25 pending free agents -- including Daniel Jones and George Pickens -- and gave intel on who might return to their current team.

59s

Are the Denver Broncos playing today? NFL Week 12 schedule, matchups, teams on a bye

While that might not be shocking to read, it certainly is in the NFL landscape. The Denver Broncos are atop the league's standings, posting a 9-2 record through 11 weeks. Their most recent victory over the Kansas City Chiefs has given the Broncos a leg up on the competition to claim the AFC West crown for the first time since 2015.