Will Josh Allen's Bills be one-and-done in the playoffs? Can the 49ers knock off the defending Super Bowl champion Eagles in Philadelphia? Chargers or Patriots in an enticing Sunday night showdown? Check out the Wild Card Weekend game picks!

Without a clear-cut favorite from the top seeds to the final wild-card teams, the playoffs figure to be as difficult to predict as all the surprises that led up to a fresh field of 14 teams. Here's breaking down our best bets to survive and advance in another round of picks and predictions against the spread: The 49ers ' offense will do its best to make up for an injury-riddled defense.