All people have two copies of every gene – one copy inherited from each parent. The NF1 gene mutation is dominant, which means that only one of the two copies of the gene needs to have the mutation to ...

Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

It is well known that neurofibromin (NF1), a tumor suppressor produced by the NF1 gene, keeps cancer growth in check by repressing the activity of a cancer driver gene called Ras. It then follows that ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

A new report describes a promising approach to studying neurofibromatosis type 1 (NF1 ... Current treatment to reduce tumor growth in patients is limited to surgery, which can lead to scarring ...