CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Authors of the PNAS article propose this three-stage model for the uncoiling of DNA from nucleosome core particles. At top, a DNA fragment 156 base pairs in length is in its most compact form, coiled ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

If parent cells and their daughter cells are to share a stable identity, parent cells must divide—and replicate their DNA—while ensuring that their histones are distributed properly to their daughter ...

Rice University scientists simulated a nucleosome coiled in DNA to discover the interactions that control its unwinding. The DNA double helix binds tightly to proteins (in red, blue, orange and green) ...

A new study shows how histones undergo correct chemical modifications during synthesis to guide new therapies.

Chromatin's structure plays an important regulatory role in DNA template-dependent processes including transcription, replication, recombination, repair, segregation, chromosomal stability, cell cycle ...