Hereditary persistence of fetal hemoglobin is a condition in which levels of HbF persist at levels greater than typically expected (less than 1%).

Sjaak Philipsen and colleagues report that haploinsufficiency for KLF1 causes hereditary persistence of fetal hemoglobin in a large Maltese family. They further show that KLF1 is a key activator ...

The action of BCL11A at the γ-globin promoter, together with the analysis of rare variants elsewhere in the promoter that cause hereditary persistence of fetal hemoglobin, suggests that ...

We found a new (δβ) 0-thalassemia deletion and a rare hereditary persistence of fetal hemoglobin deletion with identical downstream breakpoints.Comparison of the two deletions resulted in the ...

Hereditary persistence of fetal hemoglobin is exactly what it sounds like – instead of completely shutting down fetal hemoglobin production after birth like most people do, ...

This benign genetic condition is known as hereditary persistence of HbF (HPFH). The ability of fetal hemoglobin to act as a substitute for adult hemoglobin, ...

Besides being a benign genetic condition, the hereditary persistence of fetal hemoglobin could, with some help from CRISPR, lead to a new treatment for common blood disorders, such as sickle cell a ...

"Our approach to gene editing is informed by the known benefits of hereditary persistence of fetal hemoglobin," said Mitchell J. Weiss, M.D., Ph.D., chair of the St. Jude Department of Hematology ...

Patients that have what is called a hereditary persistence of fetal hemoglobin tap this resource automatically. "They have the sickle cell mutation, but additional mutations result in continued ...

Syros Presents on Identification of Novel Fetal Hemoglobin Repressor as Part of Broader Drug Discovery Program in Sickle Cell Disease at 61st Annual ASH Meeting December 08, 2019 08:00 AM Eastern ...

"Our approach to gene editing is informed by the known benefits of hereditary persistence of fetal hemoglobin," said Mitchell J. Weiss, M.D., Ph.D., chair of the St. Jude Department of Hematology ...