The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

Globin-gene mutations are a rare but important cause of cyanosis. We identified a missense mutation in the fetal Gγ-globin gene (HBG2) in a father and daughter with transient neonatal cyanosis ...

The first healthy volunteer has been dosed in a Phase 1 study of Cellarity's novel globin-switching therapy CLY-124 for ...

Japan: Researchers have found in a new study that Roxadustat therapy in non-dialyzed chronic kidney disease (CKD) patients may lead to hemoglobin (Hb) overshoot, particularly when switching ...

Hemoglobin SC disease is a genetic condition that affects your red blood cells. Learn more about common symptoms, your treatment options, and possible complications.

Hemoglobin is a vital component of your blood. Learn why doctors test your hemoglobin levels during routine blood work and what abnormal results may mean.

But where do you aim CRISPR? That’s the lesser-known story of the sickle-cell breakthrough. The disease is caused by faulty hemoglobin, the molecule that carries oxygen in the blood. To cure it ...

The $2,063,848 National Institute of Diabetes and Digestive and Kidney Diseases grant will support research on "hemoglobin switching and erythroid differentiation," the release said, noting that the ...

A retired but well-preserved mechanism for regulating viruses that has worked its way into the human genome appears to modulate a switch between adult and fetal hemoglobin production, Medical ...