Thalassemia is classified into two main types based on which part of the haemoglobin molecule is affected: Alpha Thalassemia Cause: Mutations in the genes responsible for producing alpha-globin ...

The classification depends on whether the genetic defect affects the alpha-globin or beta-globin chain of hemoglobin ... or an abnormality in the gene, the red cell’s lifespan is shorter ...

Deletions and duplications of single-base pairs typically arise during homologous recombination and cause diseases. But what happens when a mutation occurs over multiple genes?

Insertion One or more extra nucleotides are inserted into replicating DNA, often resulting in a frameshift One form of beta-thalassemia ... in the absence of all the genes in that area Cri du ...