Figure 2: Immunofluorescence staining of AγSAD mice RBCs with antibody against γ globin chain. We also assessed various hematologic parameters in these mice. Hemoglobin levels were similar in ...

When this approach was applied to blood samples from children with thalassemia, it appeared as though there was unequal labeling of the α- and β-globin chains. The problem was that there was no ...

The causative mutation is the substitution of valine for glutamic acid at the sixth position of the β globin chain (Glu6Val). Sickle cell hemoglobin (HbS) behaves like normal hemoglobin when ...

controlling the production of the beta-globin chains of haemoglobin, sickle cell disease is caused by a defect in haemoglobin itself with the presence of abnormal haemoglobin S. Both of them are ...