An organism’s DNA starts off in one lonely cell containing the germline DNA passed down from the previous generation. Through many rounds of cell division, new somatic cells emerge that contain ...

Genetic and genomic testing guide breast cancer risk assessment and treatment, as discussed by Dr. Mark Robson at the Miami ...

Determining an immunohistochemical profile to predict response to intravesical bacillus Calmette–Guérin (BCG) in patients with high-grade non-muscle invasive bladder cancer. This is an ASCO Meeting ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic ... including cancer cells, to repair DNA damage, in men with BRCA1 genetic variants, say the researchers.

Moreover, even if an organism has acquired a beneficial mutation during its lifetime, the corresponding information will not flow back into the DNA in the organism's germline. This is a ...

Genetic testing, via germline and somatic testing, is crucial in breast cancer to understand inherited risks and tumor ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic ... including cancer cells, to repair DNA damage, in men with BRCA1 genetic variants, say the researchers.

A study of 666 localised prostate tumours identified 223 driver regions, many influenced by structural variations ...

To take a closer look at homologous repair genes' contribution to prostate cancer, the investigators reviewed results of germline and somatic DNA testing from 450 patients with localized or ...