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BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
Germline BRCA 1 and BRCA 2 test results were available for all 450 men. These revealed 27 germline BRCA2 variants (6%), but only two germline BRCA1 variants (0.5%), and one of these probably wasn ...
Frontiers2d
BRCA mutations and Homologous Recombination Deficiency (HRD) testing in ovarian cancer
Ovarian cancer (OC) is the fifth most common cause of cancer-related mortality worldwide and represents the leading cause of death for gynecological malignancies. Nevertheless, over the last years, ...
CURE5d
Understanding Genetic and Genomic Testing in Breast Cancer
Genetic and genomic testing guide breast cancer risk assessment and treatment, as discussed by Dr. Mark Robson at the Miami ...
News Medical28d
Study challenges role of BRCA1 mutation in prostate cancer initiation
This indicates that BRCA2 variants, somatic and germline, have a major role in prostate cancer progression affecting at least 1 in 10 carriers with the disease, say the researchers. BRCA1 variants ...
MedPage Today6d
Second Primary Cancer Risks After Breast Cancer in BRCA1 and BRCA2 Pathogenic Variant Carriers
Opens in a new tab or window We followed 25,811 females and 480 males diagnosed with BC and tested for germline BRCA1/BRCA2 PVs in NHS Clinical Genetics centers in England between 1995 and 2019 ...
pharmaphorum6d
AZ and Owkin partner on AI to speed up BRCA testing
The germline BRCA (gBRCA) pre-screen programme has grown out of Owkin's ongoing collaboration with Gustave Roussy and the Centre Léon Bérard through PortrAIt, a French consortium to accelerate ...
Seeking Alpha3d
MYGN Myriad Genetics, Inc.
and metastatic prostate cancer with deleterious or suspected deleterious germline BRCA variants; and MyChoice CDx Companion Diagnostic test, a tumor test that determines homologous recombination ...
MedPage Today28d
BRCA1 Contribution to Prostate Cancer Called Into Question
Share on Facebook. Opens in a new tab or window Share on Bluesky. Opens in a new tab or window Share on X. Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window Mutations in ...
pharmaphorum5d
GSK hits another oncology hurdle as Zejula use is limited again
means it can only be used as second-line maintenance therapy after platinum-based chemotherapy in patients with these cancers whose tumours carry a germline BRCA mutation – around 15% of the ...
EurekAlert!28d
BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
These revealed 27 germline BRCA2 variants (6%), but only 2 germline BRCA1 variants (0.5%), and one of these probably wasn’t the driver as an ATM mutation was also present, note the researchers.
Medical Xpress27d
BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
Among those in this group who weren't tested, based on high risk—age or family history—at least 18 (just over 5%) had a germline BRCA2 variant, but only one had a germline BRCA1 (0.3%) variant ...