In eukaryotes, the tight or loose packaging of the genes in chromatin (DNA plus specific proteins) can control whether the genes can be expressed to form their encoded product. Chromatin is usually ...
Researchers turned programmable proteins into a novel genetic tool, potentially enabling tighter control of gene expression. LacI is a tetrameric protein, using two dimers to bind two specific, ...
Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...
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