New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In a new article ...

Protection Against High-Fat Diet-Induced Obesity – GDNF-tg mice exhibited significantly lower body weight and reduced fat deposition despite consuming a high-fat diet. Enhanced Fat Burning and Energy ...

GDNF does not have a neuroprotective effect in this α-synuclein-induced toxicity model of PD In the paper by Decressac et al., 2 the authors questioned the relevance and predictability of toxin-based ...

Current therapies for Parkinson disease focus mainly on symptomatic relief, but gene therapy approaches may offer the prospect of halting or reversing the progress of the disease process itself. A ...

The major goal of the research of Dr. Sidorova’s team in the Saarma lab is to develop neuroprotective and neuroregenerative drugs for disease-modifying treatment of nervous system disorders caused by ...

Infusing glial-line derived neurotrophic factor (GDNF) directly into the striatum of Parkinson disease patients fails to prevent functional decline. Moreover, it induces anti-GDNF antibodies in some ...

For the first time, researchers have witnessed dopaminergic neuron sprouting in a Parkinson disease (PD) patient treated with the neurotrophic factor GDNF. A postmortem examination of the brain of a ...

Pfizer has struck a deal with MedGenesis Therapeutix to license its glial cell line-derived neurotrophic factor (GDNF) protein and convection enhanced delivery (CED) technology to investigate ...

Glial cell line-derived neurotrophic factor (GDNF) plays a vital role in promoting motor neuron survival and axon outgrowth. It is being evaluated in clinical trials as a potential therapeutic for ...

New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In an article ...