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First of its kind gene therapy model offers hope for X-linked sideroblastic anemia treatment
Castruccio Castracani and his team developed a lentiviral vector that activated the human ALAS2 gene in erythroid cells, or cells that serve as precursors to normal red blood cells. They found ...
University of Bristol1y
Immortalised B-thalassemia and CDA IV erythroid lines
Prof. Jan Frayne’s group in the School of Biochemistry renowned for the creation of the Bristol Erythroid Line – Adult (BEL-A) immortalised cell line have expanded their portfolio and created a suite ...
Nature14d
Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3
Colony-forming cell assays indicated that the leukemic bone marrow (BM) plasma inhibited erythroid colony formation, whereas they had no inhibitory effect on other types of colonies. Cytokine ...
pharmaphorum4d
BMS announces positive Reblozyl phase 3 results for MDS
Bristol Myers Squibb has announced positive topline results from its phase 3 trial of Reblozyl (luspatercept-aamt), the first erythroid maturation ... in red blood cell transfusion independence ...