It is well understood that external electric fields can affect the integrity of cell membranes. This is due to an inherent difference between the electric potentials of the interior of a cell membrane ...

"We haven't quite made it to the promised land. We're getting close." ...

When a cell is able to take up free DNA or RNA, it is termed “competent”. Some cell types or microbial species, such as Bacillus subtilis, 11 are naturally competent and they can be induced to uptake ...

Cytokine gene transfer may provide a powerful strategy for gene therapy of cancer. The effectiveness has been demonstrated in some animal model systems. 1,2 A safe and efficient method is necessary ...

Knockout mice are animals that have been genetically modified for so that one or more genes are not expressed, or “knocked out.” Studies are then carried out on the mice to determine what the effects ...

Researchers have developed a technique that improves and cuts the cost of a technique called electroporation, which involves opening pores in cell membranes using an electric field to introduce ...

The use of either MRI-guided stereotactic ablative body radiotherapy (SABR) or CT-guided percutaneous irreversible electroporation after standard FOLFIRINOX chemotherapy did not result in any ...

RNA interference (RNAi), an important tool for gene expression and gene function analyses, can be induced by the introduction of sequence-specific small interfering RNAs (siRNAs) into cells. For an ...

Using an electric current to deliver the CRISPR/Cas9 system, in order to engineer genetic changes in laboratory mice, is highly efficient and significantly improves the system's throughput over the ...