Thymine metabolism in prokaryotes encompasses both de novo synthesis of deoxythymidine triphosphate (dTTP) via the reductive branch of pyrimidine biosynthesis and salvage pathways that recover ...

In prokaryotes, DNA replication initiates at a single defined origin and proceeds bidirectionally via a multiprotein replisome that unwinds the duplex and synthesises new strands. Elongation is ...

In a new study, published in Cell, researchers describe a newfound mechanism for creating proteins in a giant DNA virus, comparable to a mechanism in eukaryotic cells. The finding challenges the dogma ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...