DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Characterizing gene promoters and promoter–terminator combinations is crucial for maximizing the benefits of bioengineering applications in plants. However, traditional methods of identifying ...

The tools needed to pinpoint the problematic variants have been lacking. To fill this gap, Farh and his team have developed a deep neural network—PromoterAI—that accurately identifies promoter ...

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to a new gene therapy for Amyotrophic Lateral ...

Closely spaced, C-terminal ZnFs (ZnF456) recognize a specific DNA sequence, TGACCA, which is present in embryonic and fetal globin gene promoters but lacking in the adult β-globin promoter . 44 ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

Cis-regulatory elements (CREs)—including promoters, enhancers, silencers, and insulators—are critical non-coding DNA ...

Cite this: Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research - Medscape - Dec 01, 2006. Abstract and Introduction Insulin Gene Expression ...