It has some similarities to the potassium-sparing diuretic spironolactone ... or angiotensin II receptor blockers. Dose reduction of eplerenone may decrease potassium levels.

This study provided evidence of a dose-dependent antihypertensive efficacy of eplerenone but also to a single dose of spironolactone in comparison to placebo.

"Most initiators had androgen-related conditions, indications frequently requiring higher doses than ... concomitant use of ...

In a new study, de Souza and colleagues demonstrate the potent blood pressure lowering effect of low-dose spironolactone ... such as eplerenone, and studies on these selective agents should ...