The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Chemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface. Atrial fibrillation ...

It may be possible to use chemokine receptor stimulation as a means to limit entry of T cells into specific sites of ongoing stimulation such as autoimmune processes or organ transplantation.

Equities researchers at HC Wainwright lifted their Q1 2025 EPS estimates for RAPT Therapeutics in a note issued to investors ...

To this end, we employed flow cytometry-based screening to quantify the surface expression of major chemokine receptors and integrins. A significantly increased expression of CXCR3, CXCR4 ...

Their findings, published in Molecular Cell, provide new insights into the receptor’s function and could contribute to the development of targeted therapies. CXCR2, a chemokine receptor ...

Sepsis involves a complex cascade of inflammatory reactions and immune system dysregulation. Neutrophils play a crucial role in modulating the anti-inflammatory response, which is vital for managing ...

Atypical chemokine receptor 1 on nucleated erythroid cells regulates haematopoiesis Nat Immunol 18:753-761, 2017. * Reviewed in F1000, IF: 21.5. Ulvmar MH, Braun A, Werth K, Kelay P, Hub E, Eller K, ...