Normal growth requires a balance between the activity of those genes that promote cell proliferation and those that suppress it. It also relies on the activities of genes that signal when damaged ...

GTF3C2 promotes HCC cell proliferation via the USP21/MEK2/ERK1/2 pathway. General transcription factor IIIC subunit 2 (GTF3C2) is one of the polymerase III transcription-related factors.

The research shows that novel cancer drugs designed to inhibit CDK7 can, within minutes, shut down gene expression pathways that drive cell proliferation in dozens of different kinds of tissues.