Apoptosis is regulated by a family of cysteine-aspartyl proteases (caspases) that are activated in response to proapoptotic stimuli and result in disassembly of the cell through cleavage of a ...

New research has identified the Rho GTPase target ROCK-I as being cleaved by caspases during apoptosis. ROCK-I is known to stimulate actomyosin-based contractility. Once cleaved, ROCK-I is ...

Caspase Related Reagents Courtesy of Bingren Hu, Queen's Medical Center, Hawaii. Provided by Cell Signaling TechnologyConfocal micrograph of double immunostaining for cleaved caspase-3 (green) and ...

Researchers have shed new light on how tissues in the body are repaired following the damage and premature death of tissue ...

Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.

Researchers have shed new light on how tissues in the body are repaired following the damage and premature death of tissue ...

Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark of apoptosis initiation—with fluorescent dyes. Researchers often perform multiplex caspase assays ...

A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration (IDD), a primary cause of chronic lower back pain.

This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Our research ...

Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular ...