Its absorption is not affected by food. Eplerenone has an elimination half-life of 4 6 hours. Blood levels of eplerenone are increased by inhibitors of CYP3A4, such as ketoconazole and saquinavir.

Food components may alter how drugs are absorbed ... contain substances that inhibit CYP3A4 enzymes in the small intestine, ...

Dexamethasone phosphate (as sodium); 4mg/mL, 10mg/mL; soln for IV or IM inj; contains sulfites. Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens ...

Avoid food or drinks until tab dissolves ... Concomitant use or discontinuation of CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments (see full labeling).

5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole is metabolized ... among the different proton pump inhibitors (PPIs), which might influence their ...

Teemu Kantola, Effects of itraconazole and some other CYP3A4 inhibitors on the pharmacokinetics of HMG-CoA reductase inhibitors. Vilja Palkama, Studies on drug interactions between CYP3A4 inhibitors ...