It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary SALL1-SDS3 repressor construct to block transcription of target genes, ...

(Courtesy of Stanley Qi) CRISPRKit works in a similar way, though it employs dCas9, or “dead” Cas9, a deactivated version of the Cas9 enzyme unable to cut DNA. “Whereas CRISPR-Cas9 is ...

The researchers wanted to test if they could reverse these changes using epigenomic editing. So, they employed the CRISPR-dCas9 system. Like its widely used sister system CRISPR-Cas9, CRISPR-dCas9 ...

CRISPR is incredibly robust in terms of cutting DNA and targeting ... CRISPRa uses a version of Cas9 that is inactive (dCas9). It cannot cut DNA, but it progressively binds to targets using guide RNAs ...

Following these screens, the researchers tested a third tool — a CRISPR-based demethylase (Tet1-dCas9). This enzyme removes methylation, a chemical mark that silences the maternal allele.

In the world of biopharmaceutical innovation, 2024 will be remembered as CRISPR’s breakout year. In the spring, five patients with sickle cell disease began treatment with Casgevy, the first FDA ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

Evercore ISI has upgraded CRISPR Therapeutics (NASDAQ:CRSP) to outperform from in line, citing upcoming catalysts. The investment firm said it was now including the CTX320 and CTX310 in vivo ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.