Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into ...

SINGLE GUIDE RNA DESIGN AND PCR OPTIMIZATION We design and optimize CRISPR/Cas9 single or double guide RNAs for genome editing projects in mammalian cell lines. The service can be requested together ...

Ryotaro Hashizume and colleagues used the CRISPR-Cas9 gene editing system to cleave the third chromosome in previously generated trisomy 21 cell lines derived from both pluripotent cells and skin ...

But by combining a revolutionary new technology called CRISPR-Cas9 with a natural system known ... if CRISPR were used to edit a human embryo’s germ line—cells that contain genetic material ...

A recent review published in the journal Engineering delves into the significant advancements and potential of CRISPR ...

Scientists have found a way to study early embryonic development without real embryos. Using CRISPR, they programmed stem cells to self-organize into structures mimicking early embryos. The cells show ...

CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells. Verma N, Zhu Z, Huangfu D. Methods Mol Biol. 2017;1513:119-140. PMID:27807834 CRISPR/Cas9-Mediated Mutagenesis of Human Pluripotent Stem ...

Using gene editing with CRISPR-Cas9 ... the interior of egg cells and embryos has been developed, resolving a major bottleneck to using the gene-editing tool CRISPR-Cas9 in many ...

European Patent Office grants new CRISPR/Cas9 patent (EP 4 289 948 ... targets for therapeutic intervention; development of cell lines for drug discovery and screening; bioproduction of antibodies ...

CASGEVY is a non-viral, ex vivo CRISPR/Cas9 gene-edited cell therapy for eligible patients ... going to show up for us on our P&L is a single line item at this point because it’s a net cost ...

Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...