The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

Researchers resolved human transcription factor (TF) regulation Date: February 9, 2022 Source: University of Helsinki Summary: A research team introduces a new large-scale study on human ...

The transcription factor BCL11A is known to be important for determining cell properties, for example in the cerebral cortex and also in the immune system. Prof.

Genetic and functional studies have identified BCL11A as a critical mediator of the fetal-to-adult hemoglobin switch in humans and as a silencing factor for the γ-globin genes in adults. 1,25,26 ...

The BCL11A transcription factor is the protein responsible for shutting off the gene for HbF shortly after birth as the body transitions to the adult version.

There are many different kinds of transcription factors, with each acting upon defined sets of genes, sometimes with multiple transcription factors working together to regulate gene expression.

Regulation of RNAPII activity by Transcription Factors, IDRs, condensates Sequence-specific, DNA-binding TFs are the major regulators of cell identity and cell physiology. As examples, expression of ...

Transcription factor oligodeoxynucleotide (ODN) decoys are new research tools designed to enhance the study of gene regulation. The approach involves flooding the cells with enough double-stranded ...

The transcription factor BCL11A is known to be important for determining cell properties, for example in the cerebral cortex and also in the immune system. Prof.

New study provides the first comprehensive and complimentary overview on the physical and functional interactions of the human transcription factors.