Insights into biology, protein structure, ... Kai Y, et al. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells.

Destabilizing BCL11A. In the new work, Orkin and his colleagues explored the structure and chemistry of the BCL11A protein, looking for ways to hit it.

More information: Kazuki Okuyama et al, A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development, Nature Immunology (2024). DOI: 10.1038/s41590 ...

In a form of sickle cell disease called sickle cell anemia, mutations in a gene called HBB affect the protein’s structure, ... Cas9 deactivates BCL11A in bone marrow stem cells, ...

BCL11A: Evidence for neuroprotective effect Date: September 14, 2021 Source: University of Bonn Summary: The neurotransmitter dopamine influences the activity of a wide variety of brain areas.

Darren W. Logan et al. BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription. American Journal of Human Genetics , July 2016 DOI: 10.1016/j.ajhg.2016. ...

Moreover, BCL11A deletion in a mouse model substantially decreased tumor formation, ... "For this study, we stained almost 400 samples out of 2000 for BCL11A protein expression.

The researchers suspect that BCL11A plays a protective role for neurons. The study is now published in Cell Reports. ... a dark-appearing structure in the midbrain, die off.

A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development. Nature Immunology 25 , 2284–2296 (2024). doi: 10.1038/s41590-024-01997-5 Top ...