51st ASH Annual Meeting The inactivation of the BCL11A gene allowed for the increased expression of gamma-globin (the fetal form of hemoglobin) during late gestation in embryonic mice genetically ...

BCL11A: Evidence for neuroprotective effect Researchers at the University of Bonn investigate the role of the transcription factor for dopamine-producing neurons ...

Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. 2021-01-21. DOI: 10.1056/NEJMdo005939. Save. Permissions.

More information: Ge Zheng et al, A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing, Science (2024). DOI: 10.1126/science.adp3025.

Of the BCL11A alleles in CD34+ cells of the bone marrow, a mean of 78.0±11.6% were edited at month 6 (the first month assessed), a percentage that remained stable throughout follow-up .

BCL11A: Evidence for neuroprotective effect Date: September 14, 2021 Source: University of Bonn Summary: The neurotransmitter dopamine influences the activity of a wide variety of brain areas.