The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

Fu B, Liao J, Chen S, et al. CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β 0 /β 0 transfusion-dependent β-thalassemia. Nat Med 2022;28:1573-1580. Crossref ...

Researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center believe that changes to a small patch of DNA within the enhancer region of the BCL11A gene may circumvent the ...

BCL11A: Evidence for neuroprotective effect Date: September 14, 2021 Source: University of Bonn Summary: The neurotransmitter dopamine influences the activity of a wide variety of brain areas.

Six regulatory motifs (BCL11A enhancer and HBG1/2 promoter regions) were targeted using a recently developed cytosine base editor—transformer base editor (tBE).

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells. Nature Communications , 2015; 6: 5987 DOI: 10.1038/ncomms6987 Cite This Page : ...

The researchers suspect that BCL11A plays a protective role for neurons. The study is now published in Cell Reports. ... For example, the target region was not the entire striatum, ...