BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate ...

Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis.

BCL11A: Evidence for neuroprotective effect Researchers at the University of Bonn investigate the role of the transcription factor for dopamine-producing neurons ...

So when you knock BCL11A down, you simultaneously increase fetal hemoglobin and repress sickling hemoglobin, which is why we think this is the best approach to gene therapy in sickle cell disease." ...

51st ASH Annual Meeting The inactivation of the BCL11A gene allowed for the increased expression of gamma-globin (the fetal form of hemoglobin) during late gestation in embryonic mice genetically ...

Analysis did indeed show that DNA methylation of the γ-globin promoters progressively increased in BCL11A-null erythroid cells. While administration of the DNA methylation inhibitor 5-azaD to ...

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells. Nature Communications , 2015; 6: 5987 DOI: 10.1038/ncomms6987 Cite This Page : ...

So when you knock BCL11A down, you simultaneously increase fetal hemoglobin and repress sickling hemoglobin, which is why we think this is the best approach to gene therapy in sickle cell disease." ...

Higher activity of the BCL11A gene was found in approximately eight out of ten patients with basal-like breast cancer and was associated with a more advanced grade of tumour.

Specially designed lengths of RNA, injected into the bloodstream, could bind with the BCL11A gene and silence it. This approach, however, would be expensive and impractical on a large scale.

Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. 2021-01-21. DOI: 10.1056/NEJMdo005939. Save. Permissions.

BCL11A: Evidence for neuroprotective effect Date: September 14, 2021 Source: University of Bonn Summary: The neurotransmitter dopamine influences the activity of a wide variety of brain areas.