Many modern drugs are based on antibodies. These proteins very specifically identify a certain structure on the surface of ...

New active ingredients such as antibodies are usually tested individually in laboratory animals. Researchers at UZH have now ...

Astrazeneca AB has synthesized antibody-drug conjugates comprising an antibody or antigen-binding fragment covalently linked to cytotoxic moieties through enzymatically cleavable linkers reported to ...

On-demand video webcast now available here PRINCETON, N.J., March 11, 2025 (GLOBE NEWSWIRE) -- Sonnet BioTherapeutics Holdings, Inc. (the ...

The fragments also directly compromise synapses they encounter along the way, according to a preprint posted February 24 on bioRxiv. Specifically, tau fragments containing the microtubule binding ...

driven by increasing demand for smaller complex biomolecules — such as antibody fragments, nanobodies, enzymes, cytokines, various antigens, polypeptides, and plasmid DNA (pDNA) — all of which present ...

De novo antibody design has been one of the major challenges in AI-based drug discovery, requiring atomic-level precision to ...

Purified F (ab′) 2 fragments were an effective antidote to lethal SEB doses in mice and rhesus monkeys, and therefore might be a favorable candidate for treating patients with severe SEB intoxication.

Its unique antibody fragment design allows for enhanced penetration across retinal layers to reach key disease targets. These distinctive molecular characteristics position BI 771716 as a ...

The antibody in this ATC targets CD47 ... becoming activated and creating pathways that allow tumor DNA and protein fragments, which are usually destroyed, to escape. These materials are then ...