Within target cells, testosterone is converted to 5α-dihydrotestosterone (DHT), a more potent androgen, by 5α-reductase. Both testosterone and DHT bind to the AR to exert their physiological ...

Interestingly, ILC2s exhibited the highest androgen receptor (Ar) expression levels among the major immune cell types. The ...

ON ASTRAZENECA ASSAY DEVELOPMENT PROJECTS AND SUCCESSFUL COMPLETION OF EISAI CONTRACT Development of both the prostate cancer ...

Angle announced on Friday the successful completion of assay development projects for AstraZeneca and Eisai, further ...

Androgen insensitivity is an umbrella term for a number of genetic conditions where the body does not respond appropriately to testosterone and other androgens. There are multiple causes of ...

"The clinical promise of pocenbrodib, our potential best-in-class CBP/p300 inhibitor, lies not only in its remarkable efficacy in resistant prostate cancer models, but also in our sophisticated ...

Haisco Pharmaceutical Group Co. Ltd. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an androgen receptor (AR) ...

In CAH, the absence of a critical enzyme allows a 46,XX fetus to produce androgens, resulting in ambiguous external genitals. A CAH individual may have an oversized clitoris and fused labia.

Qingdao Putaike Biomedical Technology Co. Ltd. has described androgen receptor full length (AR-FL) and/or androgen receptor variant 7 (AR-v7) degradation inducers reported to be useful for the ...

Cassiopea has filled that gap with a first-in-class acne treatment, Winlevi, a topical androgen receptor (AR) inhibitor. Although the exact mechanism of action is unknown, in vitro studies show ...

sll.se Background The role of endogenous androgens for body composition and physical performance in women athletes is still not elucidated. Aim To examine the serum androgen profile in relation to ...