Receptor tyrosine kinases (RTKs) are a large group of integral membrane signaling molecules. Mutations in the RTK anaplastic lymphoma kinase (Alk) protein have been linked with non-Hodgkin lymphoma, ...

An isogenic cell line was created to model cancer patients with the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene and tested for its ...

Datroway demonstrated durable antitumor activity and an acceptable safety profile in advanced NSCLC with actionable genomic alterations, including EGFR and ALK subgroups.

and no known epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) rearrangements”, says a company statement. According to GLOBOCAN 2022 data, lung cancer remains ...

As biomarker testing and the demand for tumor-agnostic therapies rise, ROZLYTREK can potentially target a specialized yet valuable market segment. While competition from other TRK inhibitors ...