Human Lie Detector Charlie Cale is back, with guest stars including Kumail Nanjiani, Cynthia Erivo, Katie Holmes and John Mulaney.

The premise established in Season 1 has Charlie fleeing from the mob, which is another reason for her transient life on the road. But “Poker Face” doesn’t actually need a Big Bad to justify her meandering existence,

Killers and victims are played by a line-up of committed guest stars: Cynthia Erivo as identical quintuplets fighting over an inheritance; John Mulaney as an ulcer-afflicted FBI mole; Katie Holmes as a woman trapped in a loveless marriage.